摘要目的 探讨乙型肝炎肝硬化合并自发性细菌性腹膜炎(SBP)患者腹水病原菌的分布及其耐药情况,为临床合理选用抗菌药物提供指导.方法 回顾性分析117例腹水细菌培养阳性的肝硬化合并SBP患者的腹水细菌培养和药物敏感性试验结果.结果 117例腹水细菌培养阳性肝硬化合并SBP患者中,共分离出病原菌117株,其中革兰阴性菌占60.68%(71/117),革兰阳性菌占38.46%(45/117).分离菌株的耐药情况比较严重,特别是大肠埃希菌及葡萄球菌,对多种抗菌药物的耐药率均>60%.结论 乙型肝炎肝硬化合并SBP患者细菌耐药情况比较严重,应根据药物敏感性试验结果合理选用抗菌药物.

abstractsObjective To investigate distributions and drug resistance of pathogens in cirrhotic ascites comphcated with spontaneous bacterial peritonitis (SBP). Methods Results of bacterial culture and drug sensitivity tests of 117 aacitie specimens from cirrhotic patients with SBP were analyzed retrospectively. Results From the 117 ascitie specimens, 117 bacterial strains were isolated, among which 71 (60.68%)were gram-negative bacteria, 45 (38.46%) were gram-positive bacteria. The isolated strains were highly resistant to antibacterial agents, especially for Escherchia coli and Staphylococcu, the resistances to most antibiotics were above 60%. Conclusions High drug resistances were common for pathogenic bacteria in aacites of liver cirrhosis patients complicated with SBP.