摘要目的 研究近10年2型糖尿病患者尿路感染致病菌及耐药性变迁情况.方法 选择392例2型糖尿病合并尿路感染的住院患者,根据入院时间将患者分为A组(1998年1月-2002年12月)和B组(2003年1月-2007年12月),分析2组患者的临床资料、病原菌分布及主要致病菌对抗菌药物的耐药性.结果 大肠埃希菌分离率最高(50/152,32.89%),其次是白假丝酵母菌(21/152,13.82%)和屎肠球菌(15/152,9.87%).B组新分离出16种菌株.与A组比较,B组大肠埃希菌对环丙沙星和头孢曲松耐药率上升(分别为80.8%对42.8%,26.9%对0);B组屎肠球菌对四环素耐药率下降(0对100.0%).结论 2型糖尿病患者尿路感染致病菌的种类有增多趋势,且耐药形势严峻,临床上应给予重视.

abstractsObjective To investigate the transition of uropathogens and drug resistance in patients with type 2 diabetes(T2DM)complicated with urinary tract infection(UTI)in recent 10 years.Methods A total of 392 cases of T2DM with UTI were included in the study.The patients were divided into 2 groups according to time of hospitalization:group A(January 1998 to December 2002)and group B(January 2003 to December 2007).Clinical information,distilbution of uropathogens and antibiotic resistance between the two groups were analyzed.Results The most common pathogens isolated were Escherichia coli(50/152,32.89%),followed by Candida albicans(21/152,13.82%)and Enterococcus faecium(15/152,9.87%).Of the various pathogenic organisms isolated in group B,there were 16 new species not seen in group A.Escherichia coli was found to have higher resistant rates to ciprofloxacin and ceftriaxone in group B than in group A(80.8%vs.42.8%,26.9%vs.0,respectively).Enterococcus faecium was found to be more susceptibility to tetracycline in group B than in group A(0 vs.100.O%).Conclusion Species of uropathogens in T2DM patients ale increased,and the isolates are of high drug resistance,which should be noted in clinic.