慢性乙型肝炎核苷(酸)类药物治疗停药后复发的相关影响因素

Factors related to clinical relapse in patients with chronic hepatitis B after withdrawal of nucleos(t)ide analogues

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摘要核苷(酸)类药物因服用方便、不良反应小,是目前临床上广泛使用的抗HBV药物,但其停药后临床上有相当一部分患者会出现乙型肝炎复发.该文就核苷(酸)类药物抗病毒治疗的停药标准以及HBV cccDNA水平,年龄,基线丙氨酸转氨酶(ALT)、HBV DNA水平,抗病毒药物的种类,血清HBsAg水平的定量检测与动态监测,宿主免疫状态与核苷(酸)类药物停药后复发的相关性作了综述.

abstractsOral anti-viral agents nucleos (t)ide analogues (NAs) are widely used in treatment of chronic hepatitis B (CHB) since they are well-tolerated in most patients.But clinical relapse occurs in a considerable part of patients after the cessation of NAs therapy.This paper reviews factors related to clinical relapse, including time for drug withdrawal, cccDNA level, age, baseline alanine aminotransferase (ALT) and HBV DNA levels, type of NAs, serum level of HBsAg and the immune status of patients.