摘要人感染H7N9禽流感是一种新型禽源性流感病毒,于2013年3月底在上海和安徽两地率先发现,并短时间内在我国迅速蔓延,感染导致较高的发病率和病死率,引起人们的担忧和恐慌,并引发全球范围的广泛关注.对患者体内分离的H7N9病毒基因分析显示,该病毒与人类呼吸道上皮细胞的唾液酸 α-2,6型受体的亲和力较高.目前,人感染H7N9禽流感病毒的散发病例仍时有报道,冬春季相对高发.该文就近年来国内外H7N9禽流感感染患者的临床特点、流行病学及病毒基因特征的研究进展做一综述,为人感染H7N9禽流感的有效防控提供科学依据.

abstractsHuman avian-origin influenza A (H7N9)virus is a novel subtype of avian influenza A virus,which firstly emerged at the end of March 2013 in Shanghai and Anhui province.It rapidly spread in China within a short time,causing high morbidity and mortality,arousing fear and panic in public,and attracting extensive attention worldwide.The analysis of human H7N9 avian influenza virus gene shows a high affinity for α-2,6-linked sialic acid receptors expressed on human respiratory epithelial cells.At present,the sporadic cases of human H7N9 avian influenza virusare occasionally reported with an epidemic peaksat winter and spring.This article reviews clinical features,epidemiology and genetic characteristics of H7N9 avian influenza virus,proving scientific evidences foreffective prevention and control of H7N9 virus infection.