摘要在病毒性肝炎进展过程中,淋巴细胞向肝组织迁移、浸润,这对抗病毒治疗中免疫应答及炎性反应的发生起着至关重要的作用,但对其机制的研究尚未取得令人满意的答案.近年来,CXC趋化因子配体(CXC chemokine ligand, CXCL)10是目前研究较多的一个细胞因子,其受体是CXCR3,两者之间的相互作用已成为病毒性肝炎发生及发展机制的重要突破点.本文就CXCL10在病毒性肝炎中的意义以及对抗病毒疗效评估的相关研究进展作一综述.

abstractsIn the progress of viral hepatitis, lymphocytes migrate and infiltrate liver tissues, which is relevant to antiviral therapy.However, the related mechanism is still poorly understood.In recent years,CXC chemokine ligand (CXCL)10 and its receptor CXCR3 have been extensively studied.The interaction between CXCL10 and CXCR3 would be a breakthrough point for study of the mechanism of viral hepatitis pathogenesis.This article reviews the research advances of CXCL10 in the progression of viral hepatitis and in the evaluation of antiviral therapy.