摘要临床现有的针对慢性HBV感染的抗病毒治疗手段可以有效地控制HBV复制,但在绝大多数患者中仍难以实现HBsAg的清除和安全停药,即慢性乙型肝炎(CHB)的功能性治愈.机体的免疫应答在HBV的清除中起着关键作用,通过激活患者的天然免疫和适应性免疫应答有望实现对HBV感染的持续控制,从而显著提高CHB的功能性治愈率.本文对近年来CHB功能性治愈相关的免疫学研究进展进行总结.

abstractsCurrently, clinical antiviral therapies for chronic hepatitis B virus (HBV) infection can efficiently control HBV replication.However, it remains difficult to achieve HBsAg clearance and sustains off-therapy, that is the functional cure of chronic hepatitis B ( CHB) in most of patients.Host immune responses play critical roles in HBV clearance and HBV infection control by activating innate and adaptive immune responses, resulting in improving the functional cure rate of patients with CHB.This article reviews the recent advances in immunology studies related to functional cure of CHB.