换一批
换一批摘要核苷(酸)类药物和干扰素是目前治疗慢性乙型病毒性肝炎的主要药物,虽可持续抑制HBV DNA,但仍无法有效地清除HBsAg.随着对HBV生活史研究的深入和全新的直接抗病毒药物在丙型肝炎治疗上的突破,多种旨在"治愈乙型肝炎"、清除HBsAg的新药正处在临床试验或研发中.本文就慢性乙型肝炎新药的最新研究进展作一综述.
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abstractsNucleos( t) ide analogs and interferon are currently the main drugs for the treatment of chronic hepatitis B; they can induce sustained virologic suppression of HBV DNA , but still can’t clear HBsAg effectively.With the further understanding of the biology and life cycle of HBV and the breakthrough of direct antiviral agent for HCV treatment , multiple new drugs aiming at ＂cure HBV＂and clear HBsAg are undergoing preclinical development and ／or clinical trials.This article reviews the latest advances in drug therapy of chronic hepatitis B infection.
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栏目名称
DOI
10.3760/cma.j.issn.1674-2397.2019.05.014
发布时间
2019-12-12
- 浏览204
- 被引11
- 下载161
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