多胺代谢在衰老和心力衰竭过程中的作用及研究进展
Research advances in the role of polyamine metabolism in aging and heart failure
摘要衰老及衰老所致心功能受损发病率增加,多胺代谢的中间产物亚精胺、精胺及腐胺,不仅与细胞中DNA、RNA及蛋白质相互作用参在基因转录和细胞分裂,而且会伴随衰老及衰老所致心功能受损发生变化,检测其中间产物同时结合B型钠尿肽,可为全面评估衰老及衰老所致的心功能受损的心肌组织功能状态提供新的思路.
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abstractsThe incidence of aging-induced heart failure has increased.Spermidine,spermine,and putrescine,the intermediate metabolites of polyamine metabolism,not only participate in an array of crucial molecular interactions with DNA,RNA,and proteins involved in gene transcription and cell division,but also change with aging and age-associated cardiac dysfunction.Detection of serum polyamine metabolites and B type natriuretic peptide(BNP)may open up new ways for the assessment of aging and aging-induced cardiac dysfunction.
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