摘要目的 探讨血清高敏C反应蛋白(hs-CRP)在前列腺穿刺活检患者中的临床意义.方法 测定273例经直肠前列腺穿刺活检患者的hs-CRP水平.年龄44～ 95岁,平均69岁.病理诊断为前列腺癌(PCa) 96例,良性前列腺增生(BPH) 177例.比较PCa和BPH患者hs-CRP的差异,以及hs-CRP增高和正常者的前列腺穿刺阳性率.采用Logistic回归法分析hs-CRP、总PSA(tPSA)、PSA密度(PSAD)、前列腺总体积(TPV)和年龄等因素对前列腺穿刺阳性率的影响. 结果 PCa患者血清hs-CRP的中位数(上四分位数～下四分位数)为3.22 mg/L(1.22～9.84 mg/L),BPH患者为1.24 mg/L(0.55～2.76 mg/L),差异有统计学意义(P＜0.05).hs-CRP＞3 mg/L和≤3 mg/L患者的前列腺穿刺阳性率分别为55％(51/92)和25％(45/181),差异有统计学意义(P＜0.05).Logistic回归分析结果显示,hs-CRP、tPSA、TPV和年龄是影响前列腺穿刺阳性率的独立因素,hs-CRP的OR值高于tPSA、TPV和年龄. 结论 hs-CRP升高时前列腺穿刺活检的PCa检出率增加.hs-CRP是影响前列腺穿刺活检阳性率的独立因素.

abstractsObjective To assess the clinical significance of serum high sensitive C-reactive protein (hs-CRP) in patients undergone prostate biopsy.Methods A total of 273 consecutive patients were enrolled,aged 44-95 years (mean,69 years).All the patients underwent prostate biopsy.The pathological findings showed 96 cases with prostate cancer (PCa) and 177 cases with benign prostate hyperplasia (BPH).The difference of hs-CRP level between patients with PCa and those with BPH was analyzed.The positive prostate biopsy rate was compared between the patients with high hs-CRP level and those with normal hs-CRP level.Logistic regression was used to evaluate the effect of factors such as hs-CRP,tPSA,PSA density,prostate volume and age on prostate biopsy.Results The medians (interquartile range) of hs-CRP were 3.22 mg/L (1.22-9.84 mg/L) in patients with PCa and 1.24 mg/L (0.55-2.76 mg/L) in those with BPH,respectively,with significant difference(P＜0.05).The positive prostate biopsy rate in patients with high hs-CRP (＞ 3 mg/L)was 55％ (51/92),higher than that in those with normal hs-CRP (≤ 3 mg/L).The odds ratio of hs-CRP was larger than that of all other factors analyzed including tPSA,prostate volume and age according to the Logistic regression analysis.Conclusions Elevated serum hs-CRP level is associated with increased positive prostate biopsy.Serum hs-CRP acts as an independent factor increasing the positive prostate biopsy rate in patients undergone prostate biopsy.