摘要本组20例手术病人在全麻期间，静滴硝普钠（SNP）行控制性降压。静滴SNP前后进行全血氰化物（CN）和血浆硫氰酸盐（SCN）浓度测定与比较。结果显示静滴SNP以后，血CN浓度的增加与SNP滴速及总剂呈明显正相关，但SCN仅有轻微变化 。根据临床和以前动物研究结果，我们建议在麻醉期间，SNP剂量不要超过1亳克／公斤（3小时），滴速宜低于10微克／公斤／分，血CN含量须少于0.8微克／毫升。若SNP剂量超过以上界限或作长时间给药，应进行血CN和SCN测定或血气分析。

abstractsThe whole blood cyanide and plasma thiocyanate concentration in 20 anesthetic patients in whom controlled hypotention were induced with sodium nitroprusside （SNP） were determined and compared before and after infusing the drug． The results showed that these patients had considerable increase in blood cyanide concentration after infusion of SNP, but only small changes in plasma thiocyanate concen-tration. There was a close correlation between the cyanide concentration and both the rate of infusion and the total dose of SNP. On the basis of our results in human and pre-vious studies in animal, we recommend that the total dose of SNP should not exceed 1.0mg/kg or the rate of infusion should be limited to less than 10ug/kg/min during shortterm infusion （3h approximately） and that the blood cyanide concentration should not exceed 0.8ug/ml.When prolonged use with the drug, we suggest that the monitoring of the blood cyanide and the thiocyan-te concentrations and arterial blood gas analysis should be conside-red.