摘要24例控制性降压的择期颅脑手术患者随机分为二组，Ⅰ组为单纯异氟醚降压组（n=12）. Ⅱ组为异氟醚加卡托普利降压组（n=12）。两组患者的平均动脉压比降压前降低30%左右。结果显示，Ⅰ组患者血浆血管紧张素（A） Ⅱ浓度较降压前增加260%（P<0.01）； Ⅱ组患者血浆AⅡ浓度较降压前稍有下降。Ⅰ组患者诱导及维持降压的异氟醚呼气末浓度均分别高于Ⅱ组。结论认为，静注卡托普利可减弱降压期间的肾素活性及血管紧张素Ⅱ的浓度，与异氟醚合用于较长时间的控制性降压可能有其优点。

abstractsThe efficacy of intravenous captopril on plasma renin activity (PRA) and angiotensin Ⅱ (AII) during isoflurane-induced hypotension were investigated. 24 patients (aged 20~50 years,ASA Ⅰ~Ⅱ) scheduled for elective cerebral surgery were randomly divided into two groups: Group Ⅰ (isoflurane,n=12) and Group Ⅱ (captopril 0.15mg/kg plus isoflurane n=12). MAP was reduced approximately 30% in all of patients. Angiotensin Ⅱ concentration increased 260% during hypotension in group Ⅰ, but only a slight reduction in Group Ⅱ. The end-expiratory concentration of isoflurane in Group I were higher than Group Ⅱ during induced and hypotension period. It is concluded that intravenous captopril can inhibit the increase of PRA and AII concentration and less isoflurane required for the deliberated hypotension. Induced-hypotension by the combination of isoflurane with captopril may be advantageous.