摘要目的:比较多沙唑嗪和酚苄明对正常血压型嗜铬细胞瘤病人术中血流动力学的影响。方法:收集在北京大学第一医院行手术治疗的正常血压型嗜铬细胞瘤病人的围术期资料。根据病人术前服用α受体拮抗剂的种类分为酚苄明组和多沙唑嗪组。主要观察终点为术中血流动力学的波动情况，次要观察终点包括术后循环支持、并发症和死亡情况等。结果:酚苄明组24例，多沙唑嗪组37例。2组病人术中血压波动曲线下面积差异无统计学意义( P>0.05)。酚苄明组术中HR>110次/min曲线下面积大于多沙唑嗪组( P<0.05)。2组次要观察终点各指标差异无统计学意义( P>0.05)。 结论:正常血压型嗜铬细胞瘤病人术前服用多沙唑嗪或酚苄明对术中血压的影响无明显差异，而术前服用酚苄明病人术中心动过速发生风险较高。

abstractsObjective:To compare the effects of phenoxybenzamine and doxazosin on intraoperative hemodynamics in patients with normotensive pheochromocytoma.Methods:Perioperative data of patients who underwent surgery for normotensive pheochromocytoma in Peking University First Hospital from January 1, 2004 to December 31, 2017 were collected.Patients were divided into phenoxybenzamine group and doxazosin group according to the type of preoperative α-blockade.The primary endpoint was intraoperative hemodynamic fluctuations.Secondary endpoints included postoperative circulatory support, complications, mortality, and etc.Results:Sixty-one patients were included in the study, with 24 cases in phenoxybenzamine group and 37 cases in doxazosin group.There was no significant difference in the area under the curve of intraoperative blood pressure fluctuation between the two groups ( P>0.05). The area under the curve of intraoperative heart rate >110 bpm was significantly greater in phenoxybenzamine group than in doxazosin group ( P<0.05). There was no significant difference in the secondary endpoints between the two groups ( P>0.05). Conclusion:The effect of preoperative administration of doxazosin or phenoxybenzamine on blood pressure fluctuation has no significantly statistical difference in patients with normotensive pheochromocytoma, and the patients took phenoxybenzamine preoperatively have an increased risk of intraoperative tachycardia.