摘要目的:筛选非体外循环冠状动脉旁路移植术(OPCABG)后急性肾损伤(AKI)的危险因素。方法:回顾性分析2018年1月1日至2020年12月31日河南省人民医院心脏中心1 426例择期OPCABG患者病历资料，包括性别、年龄、BMI、糖尿病病史、高血压病史、高血脂病史、COPD病史、脑血管疾病史、心肌梗死病史、NYHA心功能分级、Killip分级；术前最近1次的经胸超声左室射血分数、糖化血红蛋白、葡萄糖、血清肌酐测量值；手术持续时间、术中红细胞输注、晶体液、胶体液、自体血、失血量、尿量等液体出入量；术中低血压、围术期血糖最大差值(MGD)、术后48 h和7 d内血清肌酐浓度。依据KDIGO标准定义术后AKI，以患者术后是否发生AKI分为2组：AKI组和非AKI组。采用logistic回归分析筛选OPCABG后AKI的危险因素。结果:最终纳入分析1 203例，OPCABG后AKI发生率为28.1%。logistic回归分析结果显示，BMI、高血压病史、围术期血糖MGD是OPCABG后AKI的危险因素( P<0.05)。 结论:BMI、高血压病史、围术期血糖MGD是OPCABG后AKI的危险因素。

abstractsObjective:To identify the risk factors for postoperative acute kidney injury (AKI) in patients undergoing off-pump coronary artery bypass grafting (OPCABG).Methods:The medical records of patients who underwent elective OPCABG from January 1, 2018 to December 31, 2020 from the Heart Center of Henan Provincial People′s Hospital, were retrospectively collected.The patient′s gender, age, body mass index, history of diabetes, history of hypertension, history of hyperlipidemia, history of chronic obstructive pulmonary disease, history of cerebrovascular disease, history of myocardial infarction, New York Heart Association classification of cardiac function, Killip classification, values of last left ventricular ejection fraction measured by transthoracic echocardiography before operation, glycosylated hemoglobin, glucose and serum creatinine, duration of operation, intraoperative fluid intake and output such as red blood cell infusion, crystal fluid, colloid fluid, autologous blood, blood loss and urine volume, intraoperative hypotension, perioperative maximal blood glucose difference (MGD) and serum creatinine concentrations within 48 h and 7 days were recorded.Postoperative AKI was defined according to the Kidney Disease Improving Global Outcomes criteria and the patients were divided into AKI group and non-AKI group according to whether AKI occurred after surgery.Logistic regression analysis was used to identify the risk factors for AKI after OPCABG.Results:A total of 1 203 patients were included in this study, and the incidence of AKI after OPCABG was 28.1%.Logistic regression analysis showed that body mass index, history of hypertension and perioperative MGD were risk factors for AKI after OPCABG ( P<0.05). Conclusion:Body mass index, history of hypertension and perioperative MGD are risk factors for AKI after OPCABG.