换一批持续性高尿酸血症致大鼠脂肪和骨骼肌组织IRS-1、IRS-2及GLUT-4 mRNA表达的动态变化
Influence of hyperuricemia to the expression of IRS-1, IRS-2, and GLUT-4 mRNA in fat and skeletal muscle of male rats
摘要测定高尿酸血症大鼠模型血清尿酸、胰岛素和血糖,检测脂肪、骨骼肌中葡萄糖转运蛋白4(GLUT-4)、胰岛素受体底物(IRS)-1、IRS-2 mRNA水平.结果显示,高尿酸血症大鼠造模后期脂肪骨骼肌组织中GLUT-4,IRS-2 mRNA水平低于对照组(P＜0.05).因此高尿酸血症诱发胰岛素抵抗与脂肪骨骼肌组织的GLUT-4、IRS-2的mRNA表达水平降低有关.
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abstractsBasic biochemical index were measured weekly in hyperuricemia rats.Real-time quantitative PCR technology was employed to measure glucose transporter-4 (GLUT-4),insulin receptor substrate (IRS)-1,and IRS-2 mRNA expression in the skeletal muscle and adipose tissue.The gene expression of GLUT-4 and IRS-2 are significantly lower in the last weeks of the hyperuricemia rat.Insulin resistance caused by hyperuricemia is probably related to the lowering expression levels of GLUT-4 and IRS-2 mRNA in the target tissues.
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DOI
10.3760/cma.j.issn.1000-6699.2015.10.016
发布时间
2015-12-25（万方平台首次上网日期，不代表论文的发表时间）
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