摘要目的:探讨一次果糖摄入对健康青年人血尿酸、血糖、胰岛素水平的影响。方法:纳入青年健康受试者64名，以随机数字表法随机分为25 g、50 g、75 g果糖组和75 g葡萄糖组，每组16名。采集人体学指标、血压、心率。测隔夜空腹及服用果糖或葡萄糖后30、60、120、180 min时血尿酸、血糖、胰岛素、总胆固醇、三酰甘油、低密度脂蛋白胆固醇(LDL-C)水平。结果:(1)服糖后，果糖组3 h内的血尿酸水平明显升高，以60 min时升高最为明显。25 g、50 g、75 g果糖组60 min尿酸增幅及3 h尿酸曲线下面积均显著高于75 g葡萄糖组，随着果糖剂量的增加，60 min尿酸增长率逐斩升高，差异有统计学意义(60 min尿酸增幅中位数：9.33%、13.11%、17.69%对0.75%；3 h时尿酸曲线下面积：1 674.1±410.38、1 598.3±417.03、1 504.6±292.46对1 434.8±328.94，均 P<0.01)。(2)各组血糖、胰岛素均有不同程度的升高，在30 min升高最为显著，120 min开始回落，180 min恢复到空腹水平，以75 g葡萄糖组升高最为明显( P<0.01)，其次为75 g果糖组。75 g葡萄糖组的胰岛素曲线下面积明显高于果糖组( P<0.01)，各果糖组组间差异无统计学意义；而随着果糖剂量的增加，60 min血糖、胰岛素增长率呈现显著升高趋势，以75 g果糖组升高最为明显(25 g、50 g、75 g果糖及75 g葡萄糖组的60 min血糖和胰岛素增长率中位数分别为7.40%、8.29%、13.74%、28.22%和54.29%、115.25%、185.58%、730.31%，均 P<0.01)。(3)服糖后，各组总胆固醇、三酰甘油、LDL-C的变化无明显差别( P>0.05)。 结论:一次果糖摄入可导致健康青年血尿酸、血糖、胰岛素升高，其增长幅度呈剂量依赖性。

abstractsObjective:To investigate the acute effect of fructose intake on serum uric acid, plasma glucose, and insulin levels in healthy young adults.Methods:Sixty-four healthy young subjects were recruited, and randomized to 25 g, 50 g, 75 g fructose group, and 75 g glucose group( n=16) by random number table. The anthropometric parameters, blood pressure, heart rate were measured. Several biochemistry parameters were measured, which were serum uric acid, plasma glucose, plasma insulin, serum total cholesterol, triglyceride, low density lipoprotein-cholesterol (LDL-C) at 0, 60, 120, and 180 min before and after ingestion of fructose or glucose. Results:(1) The serum uric acid level after fructose administration increased significantly than after glucose over 3 h, and peaked at 60 min. The increment of uric acid at 60 min and area under curve of uric acid at 3 h after fructose administration were significantly higher than those of glucose. The increment of uric acid at 60 min increased significantly as fructose dose was increased, especially in the 75 g fructose (increment rate of uric acid at 60 min in 25g, 50g, 75g fructose groups were 9.33%, 13.11%, 17.69% vs 0.75% respectively; Areas under curve of uric acid were 1 674.1±410.38, 1 598.3±417.03, 1 504.6±292.46 vs 1 434.8±328.94, P<0.01). (2) The glucose and insulin levels increased after fructose/glucose intake in four groups with top augment in glucose followed by 75 g fructose. The increase peaked at 30 min, began to decline at 120 min, and returned to fasting level at 180 min. The area under curve of insulin at glucose group was significantly higher than those among fructose groups. With the increase of fructose dose, the increment rate of glucose and insulin at 60 min also increased obviously, especially in the 75 g fructose (the increment rates of glucose at 60 min in 25 g, 50 g, 75 g fructose, 75 g glucose were 7.40%, 8.29%, 13.74%, 28.22% respectively; The increment rates of insulin at 60 min were 54.29%, 115.25%, 185.58%, 730.31% respectively, P<0.01). (3) There were no difference of cholesterol, triglyceride, and LDL-C after fructose/glucose ingestion. Conclusion:Acute fructose intake can lead to the increase of uric acid and insulin; Moreover, the increments of uric acid and insulin after fructose consumption were dependent on fructose dose.