摘要鲜红斑痣（PWS）是一种常见的先天血管畸形，随着患者的年龄增长，颜色逐渐加深，皮损增厚甚至形成结节。脉冲染料激光（PDL）利用选择性光热作用原理治疗 PWS，是临床治疗的标准方法。然而，对于部分难治性 PWS，单纯 PDL 治疗很难达到理想的效果，甚至根本没有作用。针对其现状，本文对增厚及结节形成的这类难治性 PWS 的多种治疗方法进行了概述，为临床治疗提供一些参考依据。

abstractsPort-wine stains(PWS)are a common congenital capillary malformation. The lesions of PWS appear to gradually darken in color and thicken with age, and even progress into nodules in late stage. Based on the principles of selective photothermolysis, pulsed dye laser (PDL)has become a standard treatment for PWS. However, for some intractable PWS, single PDL treatment shows unsatisfactory and even no effects. Considering this state, the authors summarize multiple treatment strategies for intractable PWS with thick or nodular lesions, providing a reference for their treatment.