基于DNA短串联重复序列分型分析技术精确诊断足月妊娠合并葡萄胎一例
Precision diagnosis of a full-term pregnancy with hydatidiform mole based on postnatal short tandem repeat DNA genotyping: a case report
摘要本文报告了1例通过促排卵后自然妊娠的孕妇,孕17周B超发现单胎妊娠,部分胎盘呈蜂窝样改变,孕期严密监测至孕38周剖宫产获得足月新生儿。综合临床表现,借助B超、生化检查、组织病理、免疫组化以及DNA短串联重复序列分子技术精确诊断,最终确诊为双胎之一完全性葡萄胎。随访4.5年,母儿均未见明显异常。
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abstractsWe describe a case of spontaneous conception following ovarian stimulation, in which a singleton pregnancy was revealed by ultrasound at 17 gestational weeks, with a multi-cystic "honeycomb" pattern in part of the placenta. With close monitoring, the patient delivered a healthy male neonate through cesarean section at 38 gestational weeks. The clinical findings, combined with ultrasound, laboratory, pathological, and immunohistochemistry examination, and short tandem repeat genotyping, confirmed a twin pregnancy consisting of a complete mole and coexisting fetus. No obvious abnormalities were found in the mother or the boy during a four-and-a-half-year's follow-up.
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