摘要目的 通过诱发电位(EP)监测，探讨亚低温对特重型颅脑伤的疗效。 方法 选择受伤后10h内入院的特重型颅脑伤患者(GCS≤5)24例，患者随机分为亚低温组和常温组。亚低温组体温降至32～34℃，于降温前、降温过程中及复温后监测正中神经短潜伏期体感诱发电位(SLSEP)和脑干听觉诱发电位(BAEP)；常温组在同样的时间段监测上述指标。统计分析亚低温组与常温组诱发电位的变化情况。 结果 亚低温组在治疗前后SLSEP的N20波幅变化值为(0.67±0.41)μV，常温组为(0.61±0.39)μV,两者差异无显著性意义(P＞0.05)；BAEP的V/I波幅比值，差异也无显著性意义（P＞0.05）。 结论 从神经电生理角度来看，亚低温对GCS为3～5分的特重型颅脑伤无明显疗效。

abstractsObjective To investigate the effect of mild hypothermia on mostsevere head injuries by means of evoked potentials monitoring. Methods Twenty-four patients with severe head injuries (GCS≤5) admitted within 10 hours after the injury were selected for this study. The patients were randomly divided into hypothermia or normothermia groups. Patients in the hypothermia group were cooled to 32℃-34℃. Median nerve short-latency somatosensory evoked potentials (SLSEP) and brain stem auditory evoked potentials (BAEP) were monitored before and during cooling and after rewarming. The same parameters were measured at the same time in the normothermia group. The changes in evoked potentials were analysed statistically. Results N20 amplitudes in SLSEP and ratio of I/V amplitudes in BAEP showed no significant difference between the two groups(P＞0.05). Conclusions These results demonstrate that treatment with mild hypothermia in patients with severe head injury is not significantly effective.