摘要目的 对肾盂输尿管癌预后的相关因素进行评价。 方法 回顾60例原发肾盂输尿管癌临床资料、统计流行病学、临床诊治、分子生物学相关因素20项,应用logistic回归检验各因素与术后再发膀胱癌的关系;应用Cox比例风险回归检验各因素与术后生存率的关系。 结果 与术后再发膀胱癌显著相关因素有3个:伴发膀胱癌、肿物数目及有无多部位生长。其相对危险度分别为2.89、2.20和1.60。与术后生存时间显著相关的因素有3个,为分期、有无多部位生长和VEGF表达。其风险指数分别为2.02、1.78和1.55。 结论 可以通过上述6个因素进行相对危险度和风险指数的计算,对肾盂输尿管癌的预后予以评价。
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abstractsObjective To evaluate prognosis-related factors for renal pelvicand ureteral carcinoma. Methods 60 patients with pelvic and ureteral carcinoma were studied. 20 factors in epidemiology, clinical diagnosis and therapy, and molecular biology were evaluated by logistic analysis and Cox′s hazard index analysis to present the significant factors related to prognosis. Results Associated bladder carcinoma, number of tumors and multiplace growth are related to recurrence of bladder carcinoma. Their OR values were 2.89, 2.20 and 1.60. The stage, multiplace growth, and the expression of VEGF were more significant in evaluating survival period than other factors (P<0.01), with a hazard index of 2.02,1.78 and 1.55 respectively. Conclusion The prognosis including recurrence of bladder carcinoma and survival rate can be evaluated by estimating the OR value and hazard index.
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