摘要目的 应用激光多普勒血流仪(laser doppler flowmetry,LDF)检测临床确诊为股骨头坏死患者的坏死区和头颈交界正常区的血液灌注量.方法 2007年至2008年对50例股骨头坏死患者82侧行股骨头钻孔减压自体干细胞植入,按照ARCO分期Ⅱ期为A组,46髋(ⅡA 6髋、ⅡB 22髋、ⅡC 18髋);Ⅲ期为B组,36髋(ⅢA 20髋、ⅢB 10髋、ⅢC 6髋),术中用激光多普勒血流仪检测股骨头坏死区及头颈交接区的血流灌注情况,对数据进行统计学处理.结果 A组坏死区灌注量为(30.2±3.0)PU,头颈交界区灌注量为(103.4±4.4)PU,B组坏死区灌注量为(30.6±2.8)PU,头颈交界区灌注量为(103.4±3.9)PU,A组和B组坏死区灌注量均低于正常区,二者比较差异具有统计学意义(P<0.01).而A组和B组之间坏死区和头颈交界区的灌注量差别无统计学意义(P>0.01).结论 LDF可以有效地检测股骨头坏死区血流灌注量减少,为进一步研究股骨头坏死的发病机制提供了理论依据,在股骨头坏死的研究中有应用价值.

abstractsObjective To detect the blood perfusion of the necrotic area and the femoral head and neck junction in the patients diagnosed as osteonecrosis of femoral head (ONFH) with laser doppler flowmetry (LDF). Methods From 2007 to 2008, 50 patients with ONFH 82 hips were performed core decompression and autologous stem cells transplantation. Group A was for ARCO stage Ⅱ 46 hips (Ⅱ A 6 hips、Ⅱ B 22 hips、Ⅱ C 18 hips), and Group B was for stage Ⅲ 36 hips (Ⅲ A 20 hips、Ⅲ B 10 hips、Ⅲ C 6 hips). Blood perfusion of necrotic area and femoral head and neck junction with LDP were detected during the operation. Statistical analysis was made. Results In Group A,the perfusion volume of necrotic area was (30.2±3.0) PU, and the perfusion volume of femoral head and neck junction was (103.4±4.4) PU. In Group B, the perfusion volume of necrotic area was (30.6±2.8) PU, and the peffusion volume of femoral head and neck junction was (103.4±3.9) PU. In Group A and Group B ,the perfusion volume of necrotic area was lower than that of femoral head and neck junction, and the difference was significant (P<0.01). Conclusions LDF can effectively detect that the perfusion volume of ONFH decreased, which provides a theoretical basis in order to further study the pathogenesis of ONFH. Meanwhile, there is application value of LDF on the study of ONFH.