摘要目的 研究胶质瘤1p/19q联合缺失与患者性别、年龄、肿瘤部位及病理分型是否具有相关性.方法 用荧光原位杂交法(Fluorescence in situ hybridization,FISH)对2009年1月至12月的138例胶质细胞瘤患者术后胶质瘤标本进行1P和19q缺失状态分析,男性80例,女性58例;年龄17～68岁,平均41.6岁.利用X2检验分析不同性别、年龄、肿瘤部位、病理类型的1p/19q联合缺失是否有差异.结果 星形细胞肿瘤(22.2%)的1p/19q联合缺失率显著低于少枝胶质细胞肿瘤(81.3%)和少枝星形细胞肿瘤(55.8%)(P＜0.01),少枝胶质细胞肿瘤的1p/19q联合缺失率高于少枝星形细胞肿瘤(P＜0.05).额叶胶质瘤的1p/19q联合缺失率(61.8%)显著高于颢叶(31.8%)和岛叶(34.6%)(P＜0.05).1p/19q联合缺失与患者的性别、年龄无明显相关性.结论 1p/19q联合缺失主要与胶质瘤的病理类型和部位相关,与患者的年龄和性别无明显相关性.

abstractsobjectives To find possible factors correlated with combined loss of heterozygosity (LOH)of 1 P and 19q.Methods The status of 1 P and 19q of 138 glioma specimen from January 2009 to December 2009 was evaluated by Fluorescence in situ hybridization(FISH)method,and the frequencies of combining LOH of 1 p/19q were compared between different pathologies,brain sub-regions,genders and ages.Results The frequencies of combined LOH of 1P and 19q of oligodendroglial(81.3%)and oligoastrocytic tumors(55.8%)were significantly higher than that of agtrocytic tumor(22.2%)(P＜0.01),and the frequency of oligodendroglial tumor was significantly higher than that of oligoastrocytic tumor (P＜0.05).The frequency of combining LOH of 1P and 19q in frontal lobe(61.8%)was higer than that in temporal(31.8%)and insular lobes(34.6%)(P＜0.05).Conclusion Combining LOH of 1P and 19q has significant correlation with the pathologies and brain sub-regions.