摘要目的 系统评价核基质蛋白22(NMP22)和尿细胞学对膀胱癌诊断价值.方法 制定纳入、排除标准和检索策略,检索相关文献,根据纳入、排除标准筛选文献并评价质量和提取数据,用MetaDiSc 1.4进行meta分析.结果 共检索到相关文献266篇,排除256篇,对符合纳入标准的10篇文献行meta分析,共4895例.NMP22检测膀胱癌的总灵敏度为0.76(95％ CI:0.74～0.77)、总特异度为0.80(95％ CI:0.79 ～0.82)、总受试者工作特征曲线下面积(AUC)为0.8533；尿细胞学检测总灵敏度0.36(95％ CI:0.34～0.38),总特异度0.94(95％ CI:0.93～0.95),总受试者工作特征曲线下面积为0.8628.总诊断精确度Q*指数分别为0.7863和0.7934.结论 NMP22对膀胱癌诊断的灵敏度较尿细胞学明显增高,特异度比细胞学检测低,总体诊断效能中等,与尿细胞学无明显差异,目前不能取代尿细胞学检测.

abstractsObjective Systematic reviews of diagnostic value of the nuclear matrix protein 22 (NMP22) and urine cytology for bladder cancer.Methods Development of inclusion criteria,exclusion criteria and search strategy to retrieve relevant literature.Screening the literature according to inclusion criteria and exclusion criteria.Quality evaluation of the screening and data extraction,using MetaDiSc 1.4software for Meta analysis.Results In total,266 relevant studies were searched,exeluted 256 studies,and then 10 studies were included,with 4895 patients involved.The pooled sensitivity and specificity of NMP22 to detect bladder cancer were 0.76 (95％ CI:0.74-0.77),0.80 (95％ CI:0.79-0.82),respectively.The pooled sensitivity and specificity of urine cytology were 0.36 (95％ CI:0.34-0.38),0.94 (95％ CI:0.93-0.95),respectively.The area under curve (AUC) for NMP22 and urine cytology were 0.8533 and 0.8628,and Q * index were 0.7863 and 0.7934,respectively.Conclusions For the diagnosis of bladder cancer,the sensitivity of NMP22 was higher than urine cytology,but the specificity was lower than urine cytology.Overall diagnostic performance of NMP22 was medium,it was no significant difference with urine cytology.It cant replace urine cytology now.