摘要目的 评价窄带光成像(NBI)技术结合膀胱镜(简称NBI膀胱镜)诊断膀胱癌的价值.方法 通过检索PubMed、Cochrane Library、EMbase、中国知网等数据库有关NBI膀胱镜诊断膀胱癌的临床对照研究文献,严格根据纳入及排除标准筛选文献,对符合纳入标准文献采用MetaDiSc 1.4软件进行meta分析.结果 共8篇文献被纳入,受试患者共1 022例(1 086处病灶).NBI膀胱镜和白光膀胱镜检测膀胱癌总灵敏度分别为0.943(95％CI:0.914～0.964)、0.848(95％CI:0.803 ～0.885),特异度分别为0.847(95％CI:0.812 ～0.878)、0.870(95％CI:0.831 ～0.903),阳性似然比分别为7.038(95％ CI:3.357 ～ 14.754)、6.938(95％ CI:2.052 ～ 23.465),阴性似然比分别为0.054(95％ CI:0.012 ～0.237)、0.181 (95％ CI:0.091 ～0.361),诊断优势比分别为185.32(95％CI:45.714 ～ 751.260)、42.931 (95％ CI:8.088 ～ 227.880),曲线下面积分别为0.978、0.894,Q*指数值分别为0.934、0.825.结论 NBI膀胱镜诊断膀胱癌的效能明显优于白光膀胱镜,值得临床推广.

abstractsObjectives To evaluate the value of narrow band imaging (NBI) cystoscopy in detection of bladder cancer.Methods Literatures on narrow-band imaging cystoscopy in diagnosis of bladder cancer,controlled clinical research was searched in PubMed,Cochrane Library,EMbase,and the Chinese Biomedical Literature Database.The literatures were selected according to the inclusion and exclusion criteria.The Meta-DiSc 1.4 software was used to review management and analysis.Results The 8 studies met the inclusion criteria.On a per-people analysis,the pooled sensitivity,specificity,positive likelihood ratio,negative likelihood ratio,diagnostic odds ratio (DOR) of NBI cystoscopy and white light imaging (WLI) cystoscopy were respectively 0.943 (95 ％ CI:0.914-0.964) and 0.848 (95 ％ CI:0.803-0.885),0.847 (95％CI:0.812-0.878) and 0.870 (95％ CI:0.831-0.903),7.038 (95％ CI:3.357-14.754) and 6.938 (95％CI:2.052-23.465),0.054 (95％ C I:0.012-0.237) and 0.181 (95％CI:0.091-0.361),185.32 (95％ CI:45.714-751.260) and 42.931 (95％ CI:8.088-227.880).The areas under the curve (AUC) and Q * of NBI cystoscopy and WLI cystoscopy were 0.978 and 0.894,0.934 and 0.825 respectively.Conclusion NBI cystoscopy is accurate with high diagnostic precision for diagnosis of bladder cancer.NBI cystoscopy is prior to WLI cystoscopy,but it needs more clinical evidence for further affirmance.