摘要近年来流行病学资料表明，乙肝病毒（HBV）感染是肝内胆管癌（ICC）发生发展的重要危险因素。相关文献的回顾分析结果显示，HBV相关性ICC与其他危险因素引起的ICC在临床病理学特征及治疗方面有很大差异，HBV相关性ICC患者发病年龄较轻、男性发病率高、甲胎蛋白水平较高、CA19-9水平较低、肝硬化明显而淋巴结转移率低，预后较好。这些临床病理学特征与HBV相关性肝细胞癌（HCC）具有相似性，推测可能是因为HBV相关性ICC和HBV相关性HCC的细胞起源一致。对于HBV相关性ICC的治疗，应进行以外科手术为主的综合治疗，以期达到改善预后的效果。

abstractsHepatitis B is a common and multiplex disease in China. Recently, epidemiological studies have shown that hepatitis B virus(HBV) infection is a high-risk factor for the development of intrahepatic cholangiocarcinoma(ICC). Based on a retrospective analysis of relevant literature of recent years, this article concludes that HBV-associated ICC is very different from other ICC regarding clinicopathological characteristics and treatment. Distinctive features of patients with HBV-associated ICC included younger age, preponderance of male patients, frequent elevation of alpha fetoprotein, decrease of CA19-9, frequent appearance of cirrhosis, infrequent lymph node metastasis and better prognosis. Because these clinicopathological features are similar to those of HBV-associated hepatocellular carcinoma(HCC), we speculate that the cell origin of HBV-associated ICC and HBV-associated HCC are consistent. In addition, this article also discusses that HBV-associated ICC should be treated with surgery-based comprehensive treatment in order to improve prognosis.