摘要肝内胆管癌（ICC）是仅次于肝细胞癌的第二常见的肝脏恶性肿瘤，近年来其发病率和病死率在全球范围内呈上升趋势。目前，外科手术切除是治疗ICC的最佳方法，但患者总体预后较差。精准的手术预后评估对ICC个体化治疗和改善远期疗效具有重要意义。美国癌症联合委员会TNM分期系统是ICC规范化诊疗的基石，但T分期与N分期的内容仍有待完善。通过筛选常用临床病理学参数，建立ICC列线图模型或评分系统能实现个体化的预后评估，并提高预测准确率，但均需经过更多验证研究才能走向临床应用。同时，影像学特征在建立ICC手术预后评估体系中展现出了巨大潜能，分子分型则为预后评估并筛选靶向或免疫治疗敏感人群提供精准保障。因此，在医疗大数据背景下，建立以临床病理学特征为基础、以多学科与多组学联合为核心的预后评估体系，必将有利于改善ICC外科手术的远期疗效。

abstractsIntrahepatic cholangiocarcinoma (ICC) is the second most common primary malignant tumor in the liver after hepatocellular carcinoma. Its incidence and mortality rates have increased worldwide in recent years. Surgical resection is the best treatment modality for ICC;however,the overall prognosis remains poor. Accurate evaluation of post operative prognosis allows personalized treatment and improved long-term outcomes of ICC. The American Joint Commission on Cancer TNM staging manual is the basis for the standardized diagnosis and treatment of ICC;however,the contents of stage T and stage N need to be improved. The nomogram model or scoring system established in the analysis of commonly used clinicopathological parameters can provide individualized prognostic evaluation and improve prediction accuracy;however,more studies are needed to validate the results before clinical use. Meanwhile,imaging features exhibit great potential to establish the post operative prognosis evaluation system for ICC. Molecular-based classification provides an accurate guarantee for prognostic assessment as well as selection of populations that are sensitive to targeted therapy or immunotherapy. Therefore,the establishment of a prognosis evaluation system,based on clinical and pathological characteristics and centered on the combination of multidisciplinary and multi-omics,will be conducive to improving the long-term outcomes of ICC after surgical resection in the context of big medical data.