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摘要为研究n-3脂肪酸对内皮的保护功能，以内皮通透性作指标，采用伊文氏蓝为示踪剂，使用荧光显微镜研究通透深度，使用丙酮-生理盐水抽提分光光度计测定通透量。结果表明高胆固醇血症大鼠模型内皮通透性明显增加（ P<0.001），　n-3脂肪酸可显著拮抗通透性增加（ P<0.01）。说明n-3脂肪酸对动脉粥样硬化的有益作用机制之一是保护内皮功能。

abstractsTo investigate the protective role of n-3 fatty acids on endothelium, the endothelia permeability is measured using Even's Blue as a tracer. In hypercholesterolemic rats, the percentage of Even's Blue permeating depth in aorta is determined by fluorescence microscopy, the permeating amount is measured by spectometry at 620nm after extraction by acetone 0.9% NaCl (7: 3). The results indicates that, highly elevated endothelium permeability occurrs in hypercholesterolemic rats ( P<0.001) and n-3 fatty acids can reverse this injury ( P<0.001). It is proposed that a beneficial role of n-3 fatty acids on atherosclerosis is its protective function on endothelium.