摘要目的 通过分析脑梗死患者在不同时期各向异性(FA)值的变化与患者功能恢复情况之间的关系,来研究磁共振弥散张量成像(DTI)对脑梗死后功能恢复的评估价值.方法 经磁共振和DTI检查确诊的脑梗死患者38例,按照Brunnstrom法评定患者的运动功能情况,将康复治疗后运动功能改善≥2个级别的脑梗死患者16例,设为A组;剩余运动功能未见好转的脑梗死患者22例,设为B组.分别监测2组患者病灶区和对侧在急性期、亚急性期及慢性期的各向异性值(FA值),并进行统计学分析.结果 各期检查中,2组患者病灶区的FA值较对侧均明显降低(P<0.05);2组患者急性期病灶区的FA值均高于亚急性期、慢性期病灶区的FA值(P<0.05),而亚急性期病灶区的FA值与慢性期病灶区的FA值之间没有统计学差异(P>0.05);急性期2组患者病灶区的FA值差异没有统计学意义(P>0.05),亚急性期和慢性期的2组患者病灶区的FA值之间差异有统计学意义(P<0.05).结论 脑梗死患者病灶区FA值的变化与功能恢复具有一定的规律性,对指导临床治疗及预后具有一定的参考价值.

abstractsObjective To explore the changes in fractional anisotropy (FA) among cerebral infarction pa-tients using MR diffusion tensor imaging (DTI), and to verify the relationship between any FA changes and functional recovery. Methods Thirty-eight cerebral infarction patients were divided into two groups according to their recovery level using Brunnstrom's criteria. All the patients accepted routine MR and DTI examination, and FA values were measured during the acute, subacute and chronic stages of their recovery. Results Average FA values in the lesion area were significantly lower than in the corresponding contralateral area, and were highest daring the acute stage.There was no significant difference between the subacute and chronic stages. Conclusions The FA values of cere-bral infarction patients change during the different stages of recovery with a certain regularity. This may be valuable for clinical treatment and prognosis.