摘要另枝菌属( Alistipes)细菌主要从人类肠道微生物组中分离出来,属于拟杆菌门。从人类粪便、阑尾炎、腹腔和直肠脓肿等样本中分离出了另枝菌属的各种菌种,目前该属发现的菌种有芬氏另枝菌、腐烂另枝菌、昂氏另枝菌、沙氏另枝菌和蒂莫另枝菌等。一方面,有研究表明另枝菌属细菌对某些疾病具有保护作用,包括胰腺癌、阿尔茨海默病、肝纤维化和心血管疾病等。另一方面,其他研究表明,另枝菌属细菌在帕金森病、结直肠癌和抑郁症等疾病中具有致病性。此外,另枝菌属细菌还被证明在结肠炎中表现出了矛盾的作用,既能促进结肠炎的发展,也能抑制炎症。本综述旨在帮助研究者们认识另枝菌属细菌,并且进一步总结另枝菌属细菌与疾病的关系。
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abstractsThe genus Alistipes is mailnly isolated from the human gut microbiome and belongs to the phylum Bacteroidetes. Various species of the genus Alistipes have been isolated from samples of human feces, patients with appendicitis, abdominal cavity and rectal abscesses. Currently, this genus includes species such as Alistipes finegoldii, Alistipes putredinis, Alistipes onderdonkii, Alistipes shahii and Alistipes timonensis. Some studies have shown that Alistipes has a protective effect against certain diseases, including pancreatic cancer, Alzheimer′s disease, liver fibrosis and cardiovascular disease. Conversely, other studies have shown that Alistipes is pathogenic in some diseases such as Parkinson′s disease, colorectal cancer and depression. In addition, Alistipes has also been proved to play a paradoxical role in colitis as it can promote the development of colitis and suppress inflammation. This article was to increase the understanding about the genus Alistipes and to further summarize the relationship between Alistipes and diseases.
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