摘要作者对10例肝硬化大量腹水患者进行腹水直接回输，发现随腹水回输，尿6-Keto-PGF 1α排泌量增加的同时，尿量、尿钠排量增加，而血浆肾素活性减低，提示PG合成与血容量有关。从相关分析中发现尿6-Keto-PGF 1α与尿量、尿钠排量及血浆肌酐清除率呈显著正相关，而与血浆肾素活性呈负相关，提示PGI 2所致利尿作用可能是通过增加肾脏血浆流量及肾小球滤过率。

abstractsWith sodium restriction, withdrawl of diuretic and vascular active drugs, autogenous reinfusion of ascitic fluid was carried out on 10 patients with cirrhosis and massive ascites. The effects of ascitic infusion on renal function, urinary 6-Keto-PGF 1α, TXB 2 and plasma PRA were observed. Our results show that along with ascitic infusion, 6-Keto-PGF 1α excretion and urinary flow were significantly increased, while PRA decreased. The latter indicates an increase in effective blood volume, these suggest that PG release is related to the increase in blood volume. The results also show that 6-Keto-PGF 1α correlated positively to urinary flow, sodium excretion and creatinine clearance, but not to fractional excretion of sodium. These suggest that the effect of PGI 2 on diuresis may be mediated via increasing renal plasma flow and glomerular filtration rate, but not to inhibition of sodium reabsorption by renal tube.