摘要对105例机械瓣替换术后病人的抗凝治疗进行观察，累计随访529.4病人—年。全组均持续服抗凝药，其中19例服药5个月至10年后停药。持续服药者中，Ⅰ组（维持PT比值＜2.0）71例，Ⅱ组（维持PT比值≥2.0）34例。Ⅰ组的总出血率和严重出血率分别为32.3%和7.0%，Ⅱ组为58.8%和23.5%，两组对比有显著差异（P＜0.01及P＜0.05）。人工瓣血栓形成率及栓塞率在服药组与停药组之间、Ⅰ组与Ⅱ组之间均无显著差异（P＞0.05）。我们建议：①采用PT比值1.5~2.0为抗凝治疗标准；②单纯AVR术后且符合一定条件者，可在抗凝治疗2年后停药。

abstractsWe compared the efficacy and complication of anticoagulation in 105 patients with prosthetic mechanical heart valves, The total follow-up time was 529.4 years. Out of the 105 patients taking anticoagulants, 19 interrupted the therapy after 5 months to 10 years. We divided the patients on anticoagulant into two groups. In group I (n= 21), the prothrombin time ratio was<2.0, and group II (n=34), the prothrombin-time ratio was≥2.0. The over all incidence of hemorrhage was 32.3%, but the incidence of hemorrhage and severe hemorrhage were 32.3% and 7.0% respectively in group I versus 58.8% and 23.5% in group II (p<0.01 and p<0.05). The incidence of thrombosis and the embolic event showed no significant statistical difference between anticoagulation group and group with interrupted anticoagulation, and between group I and group II (P>0.05)We suggest: (1) To take the prothombin-time ratio 1.5~2.0 as the anticoagulation standard. (2) The patients receiving single AVR and conforming to some specified conditions, can stop anticoagulation therapy after taking the anticoagulants for 2 years.