摘要糖尿病视网膜病变(DR)易感基因定位研究方法包括基于疾病生物化学代谢机制的候选基因研究和基于连锁不平衡病例对照研究以及全基因组关联研究.需要全面正确认识评估这些研究方法在DR易感基因研究中的应用现状以及所面临的挑战,充分发挥我国具有疾病资源丰富的独特优势,多学科、多地区合作,整合蛋白质组学、代谢组学和新一代测序新技术,全面分析基因-基因和基因-环境因素,推动DR易感基因研究水平的提高.

abstractsIt is clear that genetic background contributes to the development and progression of diabetic retinopathy (DR).However,the identification of susceptibility loci through candidate gene approaches,linkage disequilibrium analysis of case-control data and genome wide association study is still in its infancy and faces many challenges due to the complexity of the disease itself.China has rich resources of clinical samples.In order to facilitate elucidating the susceptibility genes of DR in China,we look forward multi-disciplinary,multi-regional collaboration studies integrating novel technologies,such as proteomics,metabolomics and next-generation sequencing to analyze gene-gene and gene-environment interaction factors comprehensively.