摘要中国有800多万盲人,其中三分之一为视网膜变性疾病所致.干细胞(SC)移植可延缓光感受器细胞变性或替代凋亡的光感器细胞,为光感受器细胞变性为病理损害特征的视网膜变性疾病治疗带来了希望.SC移植治疗致盲性眼病过程中,种子细胞是制约SC移植开展并取得成功的瓶颈问题.理想的种子细胞应当具有良好的安全性和再生能力,并且来源广泛、容易实现标准化和产业化.胚胎SC经三维培养获得的种子细胞是一种理想的种子细胞,胚胎SC三维培养是获取治疗致盲性眼病种子细胞的新策略.

abstractsThere are over 8 million blind patients in China,1/3 of them are suffered from retinal degeneration diseases.Stem cells transplantation can delay the photoreceptor cell degeneration or replace the dead photoreceptor cells,provides hopes for these patients.How to make enough seed cells is the major barrier for cell therapy.Good seed cells should be safe and with great pluripotency,and can be made from a wide range of sources,easy to be standardized and industrialized.Seed cells made from three-dimensional embryonic stem cells cultures can reach the above criteria,thus three-dimensional embryonic stem cell culture is a new strategy for making seed cells for cell treatment of blind diseases.