摘要视网膜色素上皮(RPE)细胞的功能障碍和丢失是老年性黄斑变性(AMD)等视网膜退行性病变最主要的病理特征.RPE细胞移植替代治疗是目前治疗AMD等退行性疾病最具潜能的治疗方式之一.细胞移植支架作为移植细胞的载体,既能帮助RPE细胞向视网膜下腔输送,又能促进移植细胞与宿主整合,提高RPE细胞的移植效率.细胞支架的材料来源广泛,主要有生物组织、天然聚合物、人工合成聚合物以及复合材料.应用化学改性法、等离子体表面处理法、生物分子修饰法等方式对支架进行表面修饰和改性,或调整支架的拓扑结构,能较大程度提高支架的细胞相容性,为未来细胞支架技术投入临床应用进一步奠定了基础.

abstractsReplacement of diseased retinal pigment epithelium (RPE) cells with healthy RPE cells by transplantation is one option to treat several retinal degenerative diseases including age-related macular degeneration,which are caused by RPE loss and dysfunction.A cellular scaffold as a carrier for transplanted cells,may hold immense promise for facilitating cell migration and promoting the integration of RPE ceils into the host environment.Scaffolds can be prepared from a variety of natural and synthetic materials.Strategies,such as surface modification and structure adjustment,can improve the biomimetic properties of the scaffolds,optimize cell attachment and cellular function following transplantation and lay a foundation of clinical application in the future.