摘要表观遗传学是指可遗传的非基因序列改变而引起的基因表达水平和功能上的变化,可以为执行DNA序列提供的遗传信息提供时间、位置和方式,主要包括DNA甲基化、组蛋白修饰、非编码RNA和染色质重塑.已有研究表明,表观遗传学在糖尿病视网膜病变(DR)的发生发展中起重要作用,并且通过动物实验和体外实验发现表观遗传学相关治疗方案治疗DR有一定效果.对DNA甲基化、组蛋白修饰、miRNA及代谢记忆的深入研究有利于调控糖尿病及其并发症的发生发展.对表观遗传学水平上基因转录机制变化的理解有助于我们深入研究糖尿病及其并发症的预防和控制,为治疗方法提供新思路.

abstractsEpigenetics refers to the changes in gene expression level and function caused by non-genetic sequence changes.It can provide the time,location and mode of the genetic information for the execution of DNA sequences,including DNA methylation,histone modification,non-coding RNA and chromatin remodeling.Studies had shown that epigenetics plays an important role in the development of diabetic retinopathy (DR),and it had been found that epigenetic-related treatment regimens had a certain effect on the treatment of DR through animal experiments and in vitro experiments.It was benefit to regulate the development of diabetes and its complications by depth study of DNA methylation,histone modification,miRNA and metabolic memory.An understanding of changes in gene transcriptional mechanisms at the epigenetic level could help us to further study the prevention and control of diabetes and its complications,and to provide new ideas for treatment.