摘要视神经炎(ON)是中枢神经系统的急性炎症性脱髓鞘综合征、系统性或感染性疾病的表现之一.ON发病机制仍不完全清楚,其核心是炎症及免疫因素导致视神经轴突的损伤和RGC的凋亡.部分ON患者经治疗后仍反复发作,呈缓解-复发的多相病程,称为复发性ON(RON).RON主要有慢性复发性炎症性视神经病变和复发性孤立性ON两种形式.前者是一种糖皮质激素依赖的进行性视神经病变,后者是一种不依赖糖皮质激素的非进行性RON.ON每次复发造成视神经病灶累积损伤,视觉信号传导障碍,从而导致视力不可逆性损害.深入了解ON发病机制及RON临床特点以便更好地进行临床治疗具有非常重要的意义.

abstractsOptic neuritis (ON) is one of the symptom of a central nervous system demyelinating,systemic or infectious disease.The pathogenetic mechanism of ON is still not completely clear,and its core is inflammation and immune that occurred in the optic nerve axons,and apoptosis of RGC was induced.Few patients experience recurrent episodes after treatment,presenting a remission-recurrence course of polyphasic disease,named recurrent ON (RON).Two forms of RON have been assigned:recurrent isolated optic neuritis,which is a chronic corticosteroid-dependent optic neuropathy with intermittent acute relapses,and recurrent isolated optic neuritis,which is a non-progressive relapsing ON without steroid dependence.Recurrence of ON causes cumulative damage to the optic nerve lesions and impaired visual signal transmission,thus causing irreversible damage to vision.Therefore,it is very important to have a deep understanding of the pathogenesis of ON and the clinical characteristics of RON,so as to better conduct clinical treatment.