摘要早产儿视网膜病变（ROP）发病机制尚不完全明确，其危险因素包括过度吸氧、营养不良、感染、炎症等，其中炎症对ROP的影响受到更多关注。TNF-α是一种具有广泛生物活性的蛋白，参与新生血管生成及炎症反应，其可能通过促进VEGF表达、参与并加重炎症反应、破坏血视网膜屏障及诱导细胞凋亡在ROP的发生发展中起到一定作用。了解TNF-α与ROP相关性研究的现状及进展，可为进一步研究ROP的发病机制和治疗方法提供新的思路。

abstractsThe exact pathophysiological mechanisms of retinopathy of prematurity (ROP) remain elusive. The risk factors of ROP include excessive oxygen therapy, malnutrition, infection and inflammation. Among the factors above, the effect of inflammation on ROP has received more attention. TNF-α is a biological active protein which is involved in neovascularization and inflammation. It may play a role in the development of ROP. This review summarized the studies on the association between TNF-α and ROP in recent years, so as to provide a new way to further study the pathogenesis and treatment methods of ROP.