摘要内源性色素上皮衍生因子（PEDF）因其所具有的抗血管生成作用、抗炎作用和神经保护、神经营养作用展示出作为治疗糖尿病视网膜病变（DR）药物靶点的巨大潜力。PEDF通过与细胞膜表面的受体蛋白结合，调控多种信号通路从而发挥其生物学作用。低密度脂蛋白受体相关蛋白6发挥抑制DR氧化应激反应、炎症反应和新生血管的作用，脂肪三酰甘油脂肪酶、层粘连蛋白受体、丛状蛋白结构域（PLXDC）1、PLXDC2和F1-腺嘌呤核苷三磷酸合酶均具有促进内皮细胞凋亡的作用，其中PLXDC1还具有神经保护作用。通过明确PEDF所作用的受体，探究受体与PEDF的亲和能力、疾病过程中各受体表达水平的差异，以及PEDF与特定受体结合后所发挥的特定功能，能针对受体高亲和性的活性结构域开发融合蛋白类药物，对DR的发病机制进行更清晰的理解，以PEDF或PEDF受体为靶点，夯实DR新治疗药物与治疗方法研发的理论依据。

abstractsEndogenous pigment epithelium derived factor (PEDF) shows great potential as a drug target for the treatment of diabetes retinopathy (DR) due to its anti-angiogenesis, anti-inflammatory, neuroprotective and neurotrophic effects. PEDF plays a biological role by combining with receptor proteins on cell membrane surface and regulating a variety of signaling pathways. Low density lipoprotein receptor related protein 6 plays a role in inhibiting oxidative stress reaction, inflammatory reaction, and neovascularization of DR. Adipose triglyceride lipase, laminin receptor, plexin domain containing 1 (PLXDC) 1, PLXDC2 and F 1-adenosine triphosphate synthase have the effect of promoting endothelial cell apoptosis, among which PLXDC1 also has neuroprotective effect. By clarifying the receptor that PEDF acts on, exploring the affinity between the receptor and PEDF, the difference in the expression level of each receptor in the process of disease, and the specific function that PEDF plays after binding with specific receptors, we can develop fusion protein drugs for the active domain of high affinity of receptors, have a clearer understanding of the pathogenesis of DR, and take PEDF or PEDF receptor as the target to consolidate the theoretical basis for the development of new therapeutic drugs and strategies for DR.