摘要息肉样脉络膜血管病变（PCV）最初作为独立病种被定义，但随着影像学技术的发展，现已被纳入新生血管病变谱系。在亚洲人群中，PCV的患病率较高，且随着临床研究的深入，对其病理特征、发病机制和临床表现有了更深入的认知。通过手术中对PCV病变的动态观察和组织病理学研究，可以确认其病变主要位于视网膜色素上皮和Bruch膜之间，而非源自脉络膜循环，这对于理解PCV的起源和自然病程具有重要意义。值得注意的是，虽然目前已在年龄相关性黄斑变性（AMD）/PCV之间架起了理论桥梁，但在病变局部的细胞/基质的超微结构以及分子水平的表现，尤其是AMD/PCV从早/中期病变发展到渗出型阶段的病变特征尚缺乏直观的临床资料。也正因为如此，给未来提出了极富吸引力的研究课题和探索空间。

abstractsPolypoidal choroidal vasculopathy (PCV) is originally defined as a separate disease, but with the development of imaging techniques, it has now been included in the spectrum of neovascularization. In the Asian population, the prevalence of PCV is high, and with the deepening of clinical studies, the pathological characteristics, pathogenesis and clinical manifestations of PCV have been more deeply understood. Through dynamic observation and histopathological study of PCV lesions during operation, it can be confirmed that the lesions are mainly located between the retinal pigment epithelium and the Bruch membrane, rather than originating from the choroidal circulation, which is of great significance for understanding the origin and natural course of PCV. It is worth noting that although a theoretical bridge has been established between age-related macular degeneration (AMD)/PCV, there is a lack of intuitive clinical data on the ultrastructural and molecular manifestations of the cells/stroma in the local lesions of the eye, especially the progression of AMD/PCV from early/middle stage to exudative stage. It is precisely because of this that highly attractive research topics and exploration space are proposed for the future.