摘要内在光敏性视网膜神经节细胞（ipRGC）是一种不同于视锥和视杆细胞的第3类感光细胞，其主要功能是参与调节生物体昼夜节律、瞳孔对光反应等非图片视觉活动。近期研究揭示ipRGC还与视网膜内多种突触存在相互作用，参与图片视觉，而且与多种临床疾病相关。本文针对ipRGC形态和功能特点、临床应用等方面的研究进展进行总结和分析，以期为临床工作提供参考。 （中华眼科杂志，2020，56：308-312）

abstractsIntrinsically photosensitive retinal ganglion cells (ipRGCs) are atypical photoreceptors that are different from classical cone and rod cells. The primary role of ipRGCs is to signal light for largely subconscious, non-image vision such as photoentrainment of circadian rhythm and pupillary light reflex. Recent researches have revealed additional roles for ipRGCs in communication with synapses around, conscious vision reception and pathogenesis of some diseases. Here we review the research advances of morphology, functions and clinical applications of ipRGCs. (Chin J Ophthalmol, 2020, 56: 308-312)