摘要目的 探讨肌萎缩侧索硬化(ALS)患者的平均生存时间及相关危险因素.方法 对65例ALS患者进行了随访和评估,并且采用Kaplan-Meier生存曲线的比较检验方法、t检验及方差分析等对其中33例死亡患者的平均生存时间和各相关危险因素进行分析.结果 33例ALS死亡患者从起病到死亡的平均生存时间(35±19)个月,对生存时间有影响的主要危险因素是:年龄、起病部位、疾病严重程度、从起病到诊断的间隔时间等.结论 年龄、起病部位、疾病严重程度、从起病到诊断的间隔时间等是决定ALS患者生存时间的主要危险因素.一般来讲,老年起病、以球部受累开始、症状及体征较重以及起病后能在短期内确诊的ALS患者,其生存时间较短,预后较差.

abstractsObjective To investigate the mean survival time and risk factors of amyotrophic lateral sclerosis(ALS).Methods Sixty-five ALS patients were followed up,and the clinical data of 33 of them who died were retrospectively analyzed.The survival time and related risk factors were analvsed with the statistic tools such as Kaplan-Meier survival curve,t test, and variance analysis.Results The mean survival time of the 33 patients was(35±19)months from onset of symptom.The mean survival time for the patients＜60 years old was(39±19)months;not signgicantly different from that of the patients aged ≥60years [(30±18)months,P＞0.05].The mean survival time from confirmed diagnosis was(22±17)montns.The risk factors influencing the survival time of ALS patyients were age,site of onset,severity of disease,and interval between symptom onset and diagnosis.Conclusion The prognosis of the ALS patients with elder age,bulbar onset,more severe symptoms and signs,and shorter confirmation time is poorer.