摘要目的：本研究旨在研究肺鳞癌、腺癌肿瘤的大小对淋巴结转移的不同相关性，并且阐明与纵隔淋巴结转移高发相关的肿瘤大小的临界值。方法回顾性分析上海市肺科医院2005至2006年间1346例经外科手术切除及纵隔淋巴结清扫的直径＜8 cm的肺原发性鳞、腺癌，分析肿瘤组织类型、大小与纵隔淋巴结转移相关性，以及腺、鳞癌肿瘤大小与淋巴解转移的不同结果。结果直径在2.0～2.4 cm的腺癌是淋巴结转移的危险度增加的节点，直径＞2 cm的腺癌中43％～63％，发生纵隔淋巴结转移（P＜0.01）。而在肺鳞癌中未发现这些现象（P＞0.05）。结论肺腺癌肿瘤的大小与纵隔淋巴结转移有显著相关，而肺鳞癌大小与纵隔淋巴结转移相关性不大。

abstractsObjective To explore the relationship between primary tumor size and mediastinal nodal metastases among different cell types in non-small cell lung cancer ( NSCLC) and clarify the cutoff size for a higher likelihood of metastases.Methods Retrospective evaluations were conducted for 1 346 NSCLC patients from January 2005 to January 2006.Primary focus was placed upon cases with primary tumor size <8.0 cm.Results It was shown that 2.0 cm was the critical cutoff size for increased mediastinal nodal metastases in adenocarcinoma ( P<0.01 ) , but not in squamous cell carcinoma ( P>0.05 ).Conclusion Tumor size matters differently in pulmonary adenocarcinoma and squamous cell carcinoma.