摘要目的:观察单独使用谷胱甘肽美白淡斑面膜改善黄褐斑的效果。方法:2018年6月至2019年2月，中国医学科学院皮肤病医院皮肤科入选32例黄褐斑患者，女31例，男1例，年龄28～50岁，平均37.5岁。每晚敷贴一片谷胱甘肽面膜15～20 min；4周、8周后，评估患者黄褐斑面积和严重指数(MASI指数)、医师整体评估(PGA)、患者自我评估、VISIA图像分析黑素值及皮肤病生活质量指数(DLQI)等，观察不良反应。结果:使用4周及8周后，MASI指数较基线分别下降3.66±2.59、7.00±4.51，差异有统计学意义(4周及8周时 t值分别为7.99及8.78,均 P<0.05)。平均PGA指数分别4.50分、3.33分；使用结束后，患者自我评估自觉满意者有28例，满意度87.50%；患者皮损处VISIA所测黑素值与自身对比，下降程度44.24±30.52、59.95±39.47，应用前后比较，差异均有统计学意义(4周及8周时， t值分别8.19，8.59,均 P<0.05)。应用面膜前DLQI≥16分患者21例，占65.63%，8周后DLQI≥16分减少为12例，占37.50%。使用过程中，仅1例出现一过性灼热现象，其余患者无不良反应。 结论:谷胱甘肽美白淡斑面膜可改善黄褐斑，且安全无刺激。

abstractsObjective:To observe the effect of reduced glutathione whitening facial mask (RGWFM) on melasma.Methods:Thirty two eligible patients (31 females, 1 male, aged 28-50 years, with mean 37.5 years) were recruited to use RGWFM for 15-20 min per night. Four weeks and eight weeks later, MASI, PGA, patient self-evaluation, VISIA, ILQI and side effects were evaluated.Results:After 4 weeks` and 8 weeks` treatment, MASI index was decreased for 3.66±2.59 and 7.00±4.51 compared to the base line ( t=7.99 and 8.78 after 4 weeks and 8 weeks, P<0.05). PGA was 4.50 and 3.33 at the same time. 87.50% of the patients felt satisfied. Only one patient showed a transient burning sensation on the face. Melanin value of the VISIA was decreased for 44.24±30.52 in 4 weeks later ( t=8.19, P<0.05) and decreased for 59.95±39.47 in 8 weeks later ( t=8.59, P<0.05). 65.63% of the patients DLQI score were higher than 16 points at the beginning. The percentage was 37.50% after 8 weeks. No side effect was observed in the other patients. Conclusion:It is indicated that RGWFM is safe and has certain therapeutic effects on melasma.