摘要目的:比较注射胶原蛋白、透明质酸及其联合应用治疗泪沟凹陷效果。方法:回顾性纳入2022年7月至2023年1月于西安荣耀晶肤医疗美容诊所注射治疗泪沟凹陷的女性患者60例，年龄19～49(33.6±2.2)岁，分为注射胶原蛋白组、透明质酸组、联合注射组各20例。评估术前、术后即刻及术后1、6个月患者泪槽畸形等级量表评分和术后1、6个月患者满意度。结果:3组治疗方法对泪沟凹陷的治疗均有明显改善，并在术后6个月较术前仍有显著改善。术后1个月，胶原蛋白组满意18例，占90%；透明质酸组满意16例，占80%；联合注射组满意18例，占90%。术后6个月，胶原蛋白组满意16例，占80%；透明质酸组满意16例，占80%；联合注射组满意18例，占90%。3组患者均未出现感染、栓塞、视力减退等严重并发症，透明质酸组出现色素沉着2例，胶原蛋白组色素沉着1例，联合注射组未出现色素沉着。结论:3种治疗方法均可改善泪沟凹陷，且无严重并发症。

abstractsObjective:To compare the efficacy of the injection of collagen, hyaluronic acid and their combined application in the treatment of lacrimal depression.Methods:From July 2022 to January 2023, 60 female patients with lacrimal depression, aged 19-49 years with an average age of 33.6 years, were treated by injection in Xi′an Rongyao FRESKIN Medical Cosmetology Clinic. There were 20 cases in the collagen injection group, 20 cases in the hyaluronic acid injection group, and 20 cases in the combined hyaluronic acid and collagen injection group. Preoperative, immediate, 1 month and 6 months after surgery, lacrimal groove deformity rating scale score and patient satisfaction at 1 month and 6 months after surgery were evaluated.Results:One month after operation, the satisfactory rate of patients in collagen group was 90%, that of hyaluronic acid group was 80%, and that of the combined treatment group was 90%. 6 months after operation, the satisfactory rate of patients in the collagen group was 80%, that of hyaluronic acid was 80%, and that of the combined treatment group was 90%. Postoperative follow-up showed no serious complications such as infection, embolism or visual loss in the 3 groups. Pigmentation occurred in 2 cases in the hyaluronic acid group and 1 case in the collagen group. No pigmentation occurred in the combined treatment group. Overall, all the three treatment methods were effective and safe.Conclusions:All three treatment methods can be used to improve lacrimal depression without serious complications.