摘要目的:探讨1 565 nm非剥脱点阵激光治疗面部毛孔粗大的效果。方法:该研究为纵向研究。回顾性纳入2020年9月至2021年9月宁波市第六医院整形修复重建外科就诊面部毛孔粗大患者68例，男5例、女63例，年龄20～41(29.3±4.6)岁。均采用1 565 nm非剥脱点阵激光治疗，每月治疗1次，3次为1个疗程，治疗期间用VISIA皮肤图像分析仪检测记录面部毛孔变化，比较治疗前后面部毛孔数量值、分值、百分位数排名，并观察不良反应发生情况。结果:经过1个疗程，入选者治疗前后面部毛孔数量分别为(890.75±312.61)、(834.37±289.94)个，分值分别为(25.76±1.08)、(24.81±8.59)分，治疗后面部毛孔数量、分值较治疗前下降( t＝4.19, 2.65，均 P<0.05)。入选者治疗前后面部毛孔百分位数排名分别为4.00%(2.00%, 7.00%)、5.00%(2.25%, 8.00%)，治疗后面部毛孔百分位数排名较治疗前上升( Z＝－3.35， P<0.05)。3例患者出现短暂性色素沉着，均在末次治疗后1个月内逐渐消退；1例颊部散在少许炎性丘疹，予红霉素眼膏外用涂抹后3 d消退。 结论:1 565 nm非剥脱点阵激光治疗面部毛孔粗大效果较好，不良反应较轻。

abstractsObjective:To explore the application of 1 565 nm non-ablative fractional laser in the treatment of enlarged facial pores.Methods:It was a longitudinal cohort study. From September 2020 to September 2021, 68 patients with enlarged facial pores, including 5 male patients and 63 female patients, aged between 20 and 41 (29.3±4.6) years, were treated at the Department of Plastic and Reconstructive Surgery of Ningbo Sixth Hospital. They received 1 565 nm non-ablative fractional laser once every month for a total of 3 times. The number, score and percentile ranking of facial pores before and after treatment were recorded and compared by VISIA, and adverse reactions were observed.Results:The facial pores number before and after treatment were 890.75±312.61 and 834.37±289.94, the facial pores score were 25.76±1.08 and 24.81±8.59, respectively, indicating a statistically significant decrease in facial pores number and score compared to before treatment ( t=4.19, 2.65, P<0.05). The facial pores percentile ranking before and after treatment were 4.00% (2.00%, 7.00%) and 5.00% (2.25%, 8.00%), respectively, indicating a statistically significant increase in facial pores percentile ranking compared to before treatment ( Z=-3.35, P<0.05). Three patients had transient pigmentation, all of which were gradually faded within 1 month after the last treatment. One patient had a few inflammatory papules scattered on the cheek, which faded in 3 days by using erythromycin eye cream. Conclusions:The 1 565 nm non-ablative laser can effectively improve enlarged facial pores with light adverse reactions.