摘要核因子E2相关因子2(Nrf2)是细胞维持氧化还原稳态的主要调节因子，Nrf2信号通路具有抗炎、抗氧化应激、抗纤维化等作用，在伤口愈合及病理性瘢痕形成及进展中起着重要作用。该文对氧化应激、Nrf2信号通路对病理性瘢痕作用的相关研究进行了综述，并对Nrf2信号通路、氧化应激和病理性瘢痕之间的相互关系进行了阐述，以为病理性瘢痕的机制研究及临床防治提供新的视角。

abstractsNuclear factor E2-related factor 2 (Nrf2) is a major regulator of redox homeostasis in cells, and Nrf2 signaling pathway has anti-inflammatory, anti-oxidative stress, and anti-fibrosis effects while plays an important role in wound healing and pathological scar formation and progression. This article reviewed the related research regarding the effect of oxidative stress and Nrf2 signaling pathway on pathological scars, furthermore, it investigated the relationship between Nrf2 signaling pathway, oxidative stress and pathological scars, providing a new perspective for the study of mechanism and clinical prevention and treatments of pathological scars.