摘要目的 探讨血清胃泌素释放肽前体(ProGRP)及胃蛋白酶原与胃息肉的相关性.方法 选取2017年1月至6月胃镜检查发现胃息肉的患者60例为观察组,未发现胃息肉患者60例为对照组,比较两组血清ProGRP、胃蛋白酶原I(Pepsinogen I,PGI)、胃蛋白酶原II(Pepsinogen II,PGII)水平及PGI/PGII比值差异,并比较胃息肉患者内镜下息肉摘除术后6个月内血清ProGRP、PGI、PGII水平及PGI/PGII比值变化.结果 观察组患者血清ProGRP、PGI、PGII水平明显高于对照组[ProGRP(105.88±18.10)pg/ml VS.(59.74±13.89)pg/ml,t=161.691;PGI(128.82±16.58)ng/ml VS.(81.13±8.55)ng/ml,t=229.079;PGII(16.62±1.59)ng/ml VS.(7.40±1.45)ng/ml,t=343.753;P<0.05],PGI/PGII比值低于对照组[(7.77±0.84)VS.(11.34±2.53),t=-93.190,P<0.05],不同病理类型胃息肉患者血清ProGRP、PGI、PGII水平及PGI/PGII比值无明显差异.6个月内胃息肉复发患者血清ProGRP、PGI、PGII水平及PGI/PGII比值摘除前后差异无统计学意义,息肉治愈者血清ProGRP、PGI、PGII水平较摘除前下降[ProGRP(83.41±16.15)pg/ml VS.(107.39±19.22)pg/ml,t=6.476;PGI(107.76±15.71)ng/ml VS.(128.21±16.92)ng/ml,t=6.009;PGII(11.40±1.28)ng/ml VS.(16.69±1.54)ng/ml,t=17.890;P<0.05],PGI/PGII比值升高[(9.48±1.16)VS.(7.70±0.86),t=-8.374,P<0.05].结论 ProGRP及PG可能与胃息肉有相关性,临床上可将血清ProGRP及PG水平作为评估胃息肉发病及胃息肉摘除术后复发的辅助生物学指标.