摘要1990年美国密歇根州立大学的病理学家Dixit在人类脐静脉内皮细胞中发现了一种细胞因子诱导的基因,经白细胞介素(IL)-1、PLS和肿瘤坏死因子(TNF)刺激后表达量迅速增加,并分布于体内的多种细胞中,其能编码一种特殊的锌指蛋白,该基因被命名为锌指蛋白A20基因,其编码的蛋白被命名为锌指蛋白A20,简称A20.A20是一种内源性调控蛋白,其通过抑制NF-KB的活性来抑制炎症反应,并能抑制细胞凋亡.文章将对A20的结构、功能及其临床意义作一综述.

abstractsPathologist Dixit in American Michigan University found a gene induced by cytokine from human umbilical vein endothelial cells in 1990.This gene is increased in a variety of cells rapidly and coded a special kind of the zinc finger protein when being stimulated by interleukin-1 (IL-1),PLS and tumor necrosis factor (TNF).The gene was named as zinc finger protein A20 gene,and its coding protein was named as zinc finger protein A20.A20 is a kind of endogenous regulatory protein,inhibiting the inflammatory reaction and cell apoptosis through the inhibition of NF-kappa B activity.This article mainly reviewed the structure,function and clinical significance of A20.