摘要目的 研究肺结核并发铜绿假单胞菌高突变株感染的耐药性.方法 选择我院2009年6月至2010年6月住院的肺结核患者5260例,对其标本(痰、咽拭子)分离进行细菌培养,将培养的出铜绿假单胞菌98株进行高突变检测,并对15种常用抗生素进行药敏试验.结果 在98株铜绿假单胞菌中有36例发生高突变,高突变率为36.7%,突变菌株的耐药率也显著增高.结论 肺结核并发铜绿假单胞菌的高突变发生率高,应引起全体医务人员的高度重视.

abstractsObjective To study tuberculosis complicated with pseudomonas aeruginosa infection in high-resistance mutant.Methods From June 2009 to June 2010,5260 cases of hospitalized tuberculosis patients,their samples (sputum,throat swab) separation of bacterial culture,the culture of the 98 strains of pseudomonas aeruginosa for high mutation detection,and 15 kinds of antibiotics susceptibility were tested.Results Ninty-eight strains of Pseudomonas aeruginosa,36 patients had high frequency of mutation.The high mutation rate was 36.7%,resistant mutants also significantly increased.Conclusions Pseudomonas aeruginosa pulmonary tuberculosis complicated by the high mutation rate,which should be attached great importance to all medical staff.