摘要目的:比较苯磺酸氨氯地平与硝苯地平应用于原发性高血压治疗中的临床效果。方法:抽取阳泉市第三人民院2018年2月至2019年2月收治的110例原发性高血压患者为实验对象，依据随机数字表法将入选患者分为观察组( n＝55例)及对照组( n＝55例)，其中对照组行硝苯地平治疗，观察组行苯磺酸氨氯地平治疗。观察比较两组患者的临床疗效、不良反应、舒张压(DBP)及收缩压(SBP)、血清肌酐(Scr)、内生肌酐清除率(Ccr)及其尿素氮(BUN)。 结果:治疗后，观察组总有效率(96.36%)与对照组(74.55%)比较，差异有统计学意义(χ 2＝10.532， P<0.05)。观察组患者SBP[(129.44±8.57)mmHg，1 mmHg＝0.133kPa]低于对照组[(140.35±1.67)mmHg， P<0.05]；DBP[(89.05±2.33)mmHg]低于对照组[(94.7±3.88)mmHg， P<0.05]。观察组的BUN、Scr、Ccr低于对照组，差异有统计学意义( P<0.05)。治疗后，观察组的总不良反应率(5.45%)与对照组(21.85%)比较，差异有统计学意义(χ 2＝6.253， P<0.05)。 结论:与硝苯地平相比，苯磺酸氨氯地平应用于原发性高血压治疗中具有较高的临床价值，能显著改善患者肾功能，且不良反应少，降压效果显著。

abstractsObjective:To compare the clinical effect of amlodipine bysylate and nifedipine on essential hypertension.Methods:A total of 110 patients with essential hypertension admitted to Yangquan Third People's Hospital from February 2018 to February 2019 were selected as the experimental subjects, and were divided into observation group ( n= 55) and control group ( n= 55). The control group was treated with nifedipine and observation group was treated with amlodipine besylate. The clinical effects, adverse reactions, diastolic blood pressure (DBP) and systolic blood pressure (SBP), serum creatine (Scr), clearance rate (Ccr) and urea nitrogen (BUN) of the two groups were observed and compared. Results:After treatment, the total effective rate of observation group (96.36%) was higher than that of control group (74.55%), there was significant difference between the two groups(χ 2=10.532, P<0.05). The SBP of the patients in observation group [(129.44 ±8.57) mmHg, 1 mmHg=0.133 kPa], was significantly lower than that in control group [(140.35±1.67) mmHg, P<0.05], and the DBP in observation group was (89.05 ±2.33) mmHg, which was significantly lower than that in control group [(94.7 0±3.88) mmHg, P< 0.05]. The BUN, Scr, Ccr in observation group were significantly lower than those in control group ( P< 0.05). After treatment, the total adverse reaction rate of observation group (5.45%) was significantly higher than that of control group, there was significant difference between the two groups(χ 2=6.253, P<0.05). Conclusions:Compared with nifedipine, amlodipine bysylate have higher clinical value in the treatment of essential hypertension, which can significantly improve the renal function of patients, and has less adverse reactions, and significantly antihypertensive effect.