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摘要Objective:This study aimed to identify whether brain network dynamics of patients with MUD differs from healthy controls using EEG microstate analysis.Methods:A total of 57 MUD participants and 30 matched healthy controls were recruited.Resting brain activity was recorded using 64-channel electroencephalography.The param eters of each EEG microstate were compared between the two groups.Spearm an correlation analysis was used to explore the correlation between significant microstates with drug history and cognitive functions.Results:MUD patients showed lowermean duration of microstate class A and B,and higher ratio of total time covered and globalexplained variance of microstate class C.Aberrant activation of regions of sensorin otornetwork,visualnetwork and saliency network was seen in microstate class A,B,and C,respectively.The reaction time and error rate of Stroop Task were correlated with mean duration of class B and class A,respectively.Conclusions:Resting EEG microstate is disrupted in MUD patients,which are correlated with attention bias and drug use history.